male repro

disorders induced by hormonal insufficiency

- probably ED effect

hypospadias	cryptorchidism	semen quality

histoically: sperm count decreases in the past 70 yrs

hexachlorobenzene

	prostate cell androgen-response red: DHT (control, dihydrotestosterone) blue: hexachlorobenzene two-phased dose-response curve NMDR
	'regular' dose-response monotonic the higher concentration used the higher response shown

-

experiment:

vinclozolin - anti-androgen

females: single dose i.p. injection of 50µg/kg-bw vinclozolin

mating: 6 weeks after exposure with unexposed males

male and female pups separated, males examined, females mated …

for many EDs epigenetic effect is supposed

-! NO TEST SYSTEM !-