Picrotoxin,^[1] also known as cocculin, is a poisonous crystalline plant compound, first isolated by Boullay in 1812.^[2]

Found primarily in Cocculus indicus and Anamirta cocculus, it has a strong physiological action. It acts as a noncompetitive antagonist for the GABA_A receptor (gamma-aminovajsav). As GABA itself is an inhibitory neurotransmitter, infusion of picrotoxin has stimulant and convulsant effects.

Tetrodotoxin (also known as tetrodonic acid and frequently abbreviated as TTX) is a potent neurotoxin with no known antidote. Tetrodotoxin blocks action potentials in nerves by binding to the pores of the voltage-gated, fast sodium channels in nerve cell membranes.^[1] The binding site of this toxin is located at the pore opening of the voltage-gated Na⁺ channel. Its name derives from Tetraodontiformes, the name of the order that includes the pufferfish, porcupinefish, ocean sunfish or mola, and triggerfish, several species of which carry the toxin. Although tetrodotoxin was discovered in these fish and found in several other animals (e.g., Blue-ringed Octopus, Rough-skinned newt,^[2] and Naticidae^[3]) it is actually the product of certain bacteria such as Pseudoalteromonas tetraodonis, certain species of Pseudomonas and Vibrio, as well as some others.

A botulinum toxin (gyakran botulotoxin, röviden botox vagy BTX) a Clostridium botulinum anaerob baktérium által termelt exotoxin, amely az idegrendszerben az ingerület-átvitelt zavarja meg, és így súlyos zavarokat, a mozgatórendszerben görcsöket okoz, amely a légzőizmok bénulása miatt gyorsan halálhoz vezet.