apc

Genetika

APC mutations identified in Familial Adenomatous Polyposis. LOH associated with FAP tumors

APC mutations also occur early in 85% of spontaneous colorectal Cancers

Funkció

tapasztalat: Min mice have autosomal dominant predisposition to multiple intestinal neoplasia and inactivating APC mutations. LOH associated with tumors

APC promotes degradation of β-catenin, inhibiting canonical Wnt-signaling. Defects in this signaling pathway associated with many other tumors.

β-catenin activation confers growth advantage by increasing expression of oncogenes such as c-Myc and c-Myb. It may also promote chromosomal instability by regulating mitotic spindle formation