mammlian
cytosine methyltransferases
have
been cloned
partly
characterized
|
enzyme |
function |
main
expression |
mouse -/- |
|
Dnmt1 |
maintenance |
adult/embryo |
† in ut. |
|
Dnmt3a |
de novo |
embryo |
† 4 wk |
|
Dnmt3b |
de novo |
embryo |
† in ut.* |
* Human mutation known: ICF
(Immunodeficiency, Centromeric instability and Facial anomalies syndome)