Retovirális és
celluláris onkogének
Characteristics
of Retroviral and Cellular Oncogenes
|
|
Oncogene
identified in
|
Human chromosomal location |
subcellular location of gene product |
function
of gene product |
|
|
Oncogene |
Retrovirus |
Nonviral
tumor |
|||
|
ClassI: protein kinases |
|||||
|
src |
Rous avian sarcoma pp60vsrc |
|
20 |
Plasma membrane |
Tyrosine kinase |
yes
|
Yamaguchi avian sarcoma P90gag-yes |
|
|
Plasma membrane |
Tyrosine kinase |
fys/fes
|
Fujinami avian sarcoma and feline sarcoma |
|
|
|
|
fgr
|
Gardner-Rasheed feline sarcoma P70gag-fgr |
|
1 |
|
Tyrosine kinase |
abl
|
Abelson murine leukemia P120gag-abl |
Chronic myeloid leukemia |
9 |
Plasma membrane |
Tyrosine kinase p150c-abl |
mos
|
Moloney murine sarcoma p37mos |
|
8 |
Cytoplasm |
Serine-thereonine protein kinases |
|
raf/mil (mht) |
3611 murine sarcoma, avian MH2 |
|
3 |
Cytoplasm |
|
erb-B
|
Avian erythroblastosis gp65erbB |
mammary carcinoma |
7 |
Plasma membrane |
Tyrosine kinase |
neu/erb-B2
|
|
Neuroblastoma |
17 |
Plasma membrane |
|
fms
|
MeDonough feline Sarcoma gp140v-fms |
|
5 |
Cytoplasmie membranes |
Receptor-like tyrosine kinases |
kit
|
Feline sarcoma |
|
|
Plasma membrane |
|
|
trk |
|
Colon carcinoma |
|
Plasma membrane |
|
|
ros |
URH avian sarcoma P68gag-ros |
|
6 |
Plasma membrane |
Tyrosine kinase |
|
|
Oncogene
identified in
|
Human chromosomal location |
subcellular location of gene product |
function
of gene product |
|
|
Oncogene |
Retrovirus |
Nonviral
tumor |
|||
Class II: G proteins |
|
||||
|
Ha-ras |
Harvey murine sarcoma p21v-H-ras |
Breast,skin, bladder |
11 |
Plasma membrane |
|
|
Ki-ras |
Kristen murine sarcoma p21k-K-ras |
Lung,colon carcinomas |
12 |
Plasma membrane |
GTP-Binding proteins |
|
N-ras |
Transfection studies |
Neuroblastoma, leukemia |
1 |
Plasma membrane |
|
|
|
Oncogene
identified in
|
Human chromosomal location |
subcellular location of gene product |
function
of gene product |
|
|
Oncogene |
Retrovirus |
Nonviral
tumor |
|||
|
Class III: growth
factors |
|
||||
|
sis |
Simian sarcoma virus p28sis |
|
22 |
Secreted |
PDGF b Chain |
int-I
|
|
|
11 |
Secreted |
FGF Chain |
HTS
|
|
|
11 |
Secreted |
FGF Chain |
|
|
Oncogene
identified in
|
Human chromosomal location |
subcellular location of gene product |
function
of gene product |
|
|
Oncogene |
Retrovirus |
Nonviral
tumor |
|||
|
Class IV: nuclear
proteins |
|
||||
myc
|
Avian MC29 P110gag-myc |
Small-cell ung carcinoma (SCLC) |
8 |
Nucleus |
|
|
N-myc |
|
Neuroblastomas SCLC |
2 |
Nucleus |
|
L-myc
|
|
SCLC |
1 |
Nucleus |
|
|
myb |
Avian myeloblastosis P48v-myb |
Leukemias |
6 |
Nucleus |
|
fos
|
FBJ Osteosarcoma pp55 |
|
14 |
Nucleus |
|
ski
|
Avian SKV770 ?P110.P125 |
|
1 |
Nucleus |
|