a p53-működés módosításai

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(a) PRMT5 mediates arginine methylation of p53. PRMT5 associates with the cofactor Strap, which associates with additional cofactors JMY and p300/CBP. These cofactors associate with p53. Sites of methylation on p53 are shown.

Strap, which has an unusual structure, being composed almost entirely of a tandem series of six tetratricopeptide repeat (TPR) motifs

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 (b) Coordination of p53 modifications. P300/CBP acetylates p53, which leads to histone acetylation. Similarly, PRMT5 methylation of histones may be triggered by p53 methylation.