a p53-működés módosításai
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(a) PRMT5 mediates arginine methylation of
p53. PRMT5 associates with the cofactor Strap,
which associates with additional cofactors JMY and p300/CBP. These cofactors
associate with p53. Sites of methylation on p53 are shown. Strap, which has an unusual
structure, being composed almost entirely of a tandem series of six tetratricopeptide repeat (TPR) motifs |
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(b)
Coordination of p53 modifications. P300/CBP acetylates p53, which leads to histone acetylation. Similarly, PRMT5
methylation of histones may be triggered by p53 methylation. |