CARBACHOL kolinerg szintetikus készítmény, de stimulálja a transzkripciót

- M3 receptor

A single transmitter regulates gene expression through two separate mechanisms: cholinergic regulation of phenylethanolamine N- methyltransferase mRNA via nicotinic and muscarinic pathways
MJ Evinger, P Ernsberger, S Regunathan, TH Joh and DJ Reis Journal of Neuroscience, Vol 14, 2106-2116, 1994

Cholinergic Stimulation of AP-1 and NFB Transcription Factors Is Differentially Sensitive to Oxidative Stress in SH-SY5Y Neuroblastoma: Relationship to Phosphoinositide Hydrolysis
Xiaohua Li, Ling Song, and Richard S. Jope Journal of Neuroscience, Vol 16, 5914-5922, 1996

Transcription factor activation and mitogenic synergism in airway smooth muscle cells
T.L. Ediger¹, N.A. Schulte¹, T.J. Murphy² and M.L. Toews¹ Eur Respir J 2003; 21:759-769

PDGF – vérlemezke-eredetű növekedési faktor

– receptor: Y-kináz (ras – raf – MAPK - erk út)

TPA - 12-O-tetradecanoyl-13-acetate (tetra-phorbol-acetát - TPA)

- receptor: citoplazma, protein kinase C

AP-1 DNA-binding activity consists primarily of

JunD, c-Fos, and Fra-1,

and is accompanied with the

increased expression and phosphorylation of

these subunits.