Possible
toxication and detoxification pathways of xenobiotic compounds:
|
(1) direct toxic effect
(A); (2) metabolic activation; (3) formation of a stable
metabolite which may cause a toxic effect (C); (4) detoxification. |
The
reactive metabolite formed by bioactivation (2) may cause a toxic effect (B)
through reaction with critical targets (5) or be detoxified through reaction
with a protective agent (6). |